| AAPPS Bulletin
Vol. 16 No. 3,
June 2006 |
Highlight of the Issue
A Novel Simulation Approach to Forced Unfolding Single RNAs
(PDF, 757KB)
Fei Liu
Center for Advanced Study,
Tsinghua University, Beijing, China
Abstract
We summarize our recent simulation progress of
micromanipulation experiments on RNAs. We mainly consults with
two important small RNAs unfolding experiments carried out by
Bustamante group. Our results show that, in contrast to protein
cases, using the single polymer elastic theory and the well
known RNA secondary structure free energy knowledge, we can
successively simulate various behaviors of the forced unfolding
single RNAs under different experimental setups from equilibrium
to far-from equilibrium. |
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