| AAPPS Bulletin
Vol. 16 No. 3,
June 2006 |
Highlight of the Issue
Effects of Local Inhomogeneities on the Mechanical Responses
of Single DNAs (PDF,
805KB)
Jie Yan
Department
of Physics,
National University of Singapore, Singapore
Abstract
We summarize our recent development of the exact computation
for the statistical mechanics of semifexible polymers subject to
a tensile force. By using a discretized semifexible polymer
model and a transfer-matrix approach, we developed a novel
method to compute the total partition function and the partition
function with constraints of the end-to-end distance and the
orientational boundary conditions.
We applied our theory to the study of the statistical
mechanics of the double helix DNAs, focused on the effects of
local inhomogeneities arising from protein binding on various
mechanical responses of single DNAs. |
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